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Physiological functions and clinical implications of the N-end rule pathway
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《医学前沿(英文)》 2016年 第10卷 第3期 页码 258-270 doi: 10.1007/s11684-016-0458-7
The N-end rule pathway is a unique branch of the ubiquitin-proteasome system in which the determination of a protein’s half-life is dependent on its N-terminal residue. The N-terminal residue serves as the degradation signal of a protein and thus called N-degron. N-degron can be recognized and modifed by several steps of post-translational modifications, such as oxidation, deamination, arginylation or acetylation, it then polyubiquitinated by the N-recognin for degradation. The molecular basis of the N-end rule pathway has been elucidated and its physiological functions have been revealed in the past 30 years. This pathway is involved in several biological aspects, including transcription, differentiation, chromosomal segregation, genome stability, apoptosis, mitochondrial quality control, cardiovascular development, neurogenesis, carcinogenesis, and spermatogenesis. Disturbance of this pathway often causes the failure of these processes, resulting in some human diseases. This review summarized the physiological functions of the N-end rule pathway, introduced the related biological processes and diseases, with an emphasis on the inner link between this pathway and certain symptoms.
关键词: N-end rule pathway Ate1 cardiovascular development neurogenesis spermatogenesis neurodegenerative disorders Johanson–Blizzard syndrome
End-use energy utilization efficiency of Nigerian residential sector
OHUNAKIN,Bethrand N. NWANKWOJIKE,Ekwe B. EKWE
《能源前沿(英文)》 2014年 第8卷 第3期 页码 322-334 doi: 10.1007/s11708-014-0329-3
关键词: end-use energy exergy efficiency residential sector Nigeria
Entity and relation extraction with rule-guided dictionary as domain knowledge
《工程管理前沿(英文)》 页码 610-622 doi: 10.1007/s42524-022-0226-0
关键词: entity extraction relation extraction prior knowledge domain rule
《能源前沿(英文)》 2023年 第17卷 第2期 页码 211-227 doi: 10.1007/s11708-022-0847-3
关键词: end-to-end learning microgrids voltage profile improvement generative adversarial network
《环境科学与工程前沿(英文)》 2023年 第17卷 第3期 doi: 10.1007/s11783-023-1637-9
● Converting xylose to caproate under a low temperature of 20 °C by MCF was verified.
关键词: Xylose fermentation Caproate Low temperature Bifidobacterium FAB pathway RBO pathway
Clinical applications of neurolinguistics in neurosurgery
Peng Wang, Zehao Zhao, Linghao Bu, Nijiati Kudulaiti, Qiao Shan, Yuyao Zhou, N. U.
《医学前沿(英文)》 2021年 第15卷 第4期 页码 562-574 doi: 10.1007/s11684-020-0771-z
关键词: neurolinguistics language mapping dual pathway model neurosurgery
Juan LIU, Fei QIAO, Yumin MA, Weichang KONG
《工程管理前沿(英文)》 2018年 第5卷 第4期 页码 507-514 doi: 10.15302/J-FEM-2018045
The NP-hard scheduling problems of semiconductor manufacturing systems (SMSs) are further complicated by stochastic uncertainties. Reactive scheduling is a common dynamic scheduling approach where the scheduling scheme is refreshed in response to real-time uncertainties. The scheduling scheme is overly sensitive to the emergence of uncertainties because the optimization of performance (such as minimum make-span) and the system robustness cannot be achieved simultaneously by conventional reactive scheduling methods. To improve the robustness of the scheduling scheme, we propose a novel slack-based robust scheduling rule (SR) based on the analysis of robustness measurement for SMS with uncertain processing time. The decision in the SR is made in real time given the robustness. The proposed SR is verified under different scenarios, and the results are compared with the existing heuristic rules. Simulation results show that the proposed SR can effectively improve the robustness of the scheduling scheme with a slight performance loss.
关键词: semiconductor manufacturing system uncertain processing time dynamic scheduling slack-based robust scheduling rule
毕建欣,张岐山
《中国工程科学》 2005年 第7卷 第4期 页码 88-94
介绍了关联规则挖掘算法的基本原理,并按照挖掘中涉及到的变量数目(维数)、数据的抽象层次和处理变量的类别(布尔型和数值型),依次对关联规则挖掘算法的研究进行综述,并对一些典型的算法进行分析和比较,最后展望了关联规则挖掘算法的研究方向。
《医学前沿(英文)》 2023年 第17卷 第4期 页码 714-728 doi: 10.1007/s11684-022-0959-5
关键词: FRMD6 lung cancer mTOR pathway
Exploring the methodology and application of clinical pathway in evidence-based Chinese medicine
Sicheng Wang, He Yu, Jianping Liu, Baoyan Liu
《医学前沿(英文)》 2011年 第5卷 第2期 页码 157-162 doi: 10.1007/s11684-011-0128-8
关键词: evidence-based medicine clinical pathway methodology concept technical difficulty
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《医学前沿(英文)》 2017年 第11卷 第3期 页码 403-409 doi: 10.1007/s11684-017-0522-y
Tissue factor pathway inhibitor (TFPI) is the main inhibitor of tissue factor-mediated coagulation. TFPI is expressed by endothelial and smooth muscle cells in the vasculature. Endothelium-derived TFPI has been reported to play a regulatory role in arterial thrombosis. However, the role of endogenous TFPI in vascular smooth muscle cells (VSMCs) in thrombosis and vascular disease development has yet to be elucidated. In this TFPIFlox mice crossbred with Sma–Cre mice were utilized to establish TFPI conditional knockout mice and to examine the effects of VSMC-directed TFPI deletion on development, hemostasis, and thrombosis. The mice with deleted TFPI in VSMCs (TFPISma) reproduced viable offspring. Plasma TFPI concentration was reduced 7.2% in the TFPISma mice compared with TFPIFlox littermate controls. Plasma TFPI concentration was also detected in the TFPITie2 (mice deleted TFPI in endothelial cells and cells of hematopoietic origin) mice. Plasma TFPI concentration of the TFPITie2 mice was 80.4% lower (P<0.001) than that of the TFPIFlox mice. No difference in hemostatic measures (PT, APTT, and tail bleeding) was observed between TFPISma and TFPIFlox mice. However, TFPISma mice had increased ferric chloride–induced arterial thrombosis compared with TFPIFlox littermate controls. Taken together, these data indicated that endogenous TFPI from VSMCs inhibited ferric chloride–induced arterial thrombosis without causing hemostatic effects.
关键词: arterial thrombosis conditional knockout mice tissue factor pathway inhibitor vascular smooth muscle cells
Study on the NOx release rule along the boiler during pulverized coal combustion
JIN Jing, ZHANG Zhongxiao, LI Ruiyang
《能源前沿(英文)》 2007年 第1卷 第1期 页码 91-95 doi: 10.1007/s11708-007-0009-7
一种端到端语音合成中的高效解码自注意力网络 Research Article
赵伟1,2,许力1,2
《信息与电子工程前沿(英文)》 2022年 第23卷 第7期 页码 1127-1138 doi: 10.1631/FITEE.2100501
关键词: 高效解码;端到端;自注意力网络;语音合成
《医学前沿(英文)》 2022年 第16卷 第4期 页码 637-650 doi: 10.1007/s11684-021-0864-3
关键词: apigenin aminoglycosides ototoxicity oxidative stress Nrf2 signaling pathway
Comparison on End-of-Life strategies of WEEE in China based on LCA
Bin Lu, Xiaolong Song, Jianxin Yang, Dong Yang
《环境科学与工程前沿(英文)》 2017年 第11卷 第5期 doi: 10.1007/s11783-017-0994-7
关键词: End-of-Life Waste electrical and electronic equipment Life cycle assessment Reuse
标题 作者 时间 类型 操作
End-use energy utilization efficiency of Nigerian residential sector
OHUNAKIN,Bethrand N. NWANKWOJIKE,Ekwe B. EKWE
期刊论文
Topology-independent end-to-end learning model for improving the voltage profile in microgrids-integrated
期刊论文
Low-temperature caproate production, microbial diversity, and metabolic pathway in xylose anaerobic fermentation
期刊论文
Clinical applications of neurolinguistics in neurosurgery
Peng Wang, Zehao Zhao, Linghao Bu, Nijiati Kudulaiti, Qiao Shan, Yuyao Zhou, N. U.
期刊论文
Novel slack-based robust scheduling rule for a semiconductor manufacturing system with uncertain processing
Juan LIU, Fei QIAO, Yumin MA, Weichang KONG
期刊论文
FERM domain-containing protein FRMD6 activates the mTOR signaling pathway and promotes lung cancer progression
期刊论文
Exploring the methodology and application of clinical pathway in evidence-based Chinese medicine
Sicheng Wang, He Yu, Jianping Liu, Baoyan Liu
期刊论文
Endogenous tissue factor pathway inhibitor in vascular smooth muscle cells inhibits arterial thrombosis
null
期刊论文
Study on the NOx release rule along the boiler during pulverized coal combustion
JIN Jing, ZHANG Zhongxiao, LI Ruiyang
期刊论文
Apigenin alleviates neomycin-induced oxidative damage via the Nrf2 signaling pathway in cochlear hair
期刊论文